Human Genes may hold answers to liver cancer Photo Credit: Creative Commons
The human genome houses a complex network, a recent study of the genome claims to contain answers to treating liver cancer. By identifying specific human genetic codes involved in liver function, researchers are unraveling key dynamics of the human liver that may provide new ways to prevent and cure liver diseases.
In a massive research project led by Imperial College London, 61,000 participants joined in one of the largest studies ever conducted on human genes and the liver. The project was designed to locate the regions in the genes that are responsible for processes in the liver. Researchers successfully identified 32 new regions in the genes that regulate proper liver function.
Professor Paul Elliot, a senior author of this research, explained how liver problems affect a considerable number of the world’s population, causing devastating effects on their quality of life. The discovery of these new genetic regions opens a whole new dimension to better understand the liver, and ultimately, to develop treatments for various liver diseases.
The researchers used a genome-wide association framework to evaluate the different components and structures of the participants’ genes. They also looked at the concentration of liver enzymes in the blood collected, which could indicate if the subject is at risk to a certain disease. For example, a high enzyme concentration could be a symptom of cardiovascular conditions, diabetes or liver diseases such as cirrhosis. Cross-checking these genetic and blood data aided researchers in locating regions involved in liver function.
The study was also able to determine 69 genes engaged in liver function that also play significant roles in ensuring the body’s immunity and metabolism. Such breakthrough in liver research is an important leap towards understanding the interplay of genetics and organ function. More importantly, it provides new avenues towards finding solutions for livers that no longer function properly, and making these treatments immediately available to the millions who are suffering from liver cancer.
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We need someone to look at the genetic liver disease that has plagued our family. Mother died with Hemachromatosis, Cirrhosis and Primary liver disease.
Baby sister Died Feb 2011 with Cirrhosis – Bled out internally
52 year sister has Lupus and Hemachromatosis
54 year sister has Rheumoatoid Arthritis and Chronic Bronchitis. Was just found to have AST and ALT counts. In the beginning of the process.
With such a tragic family history of liver disease we are hoping that you will take the time to research our family to help our children and grandchildren even if you can not help us the last 2 living.
Thanks for your time.